ABSTRACT
Neuroendocrine neoplasms (NENs) are a heterogeneous group of tumors with distinct morphological and biological manifestations, the liver being the main organ affected by its metastases. However, primary hepatic involvement is quite rare. Hepatic NENs can have a variety of radiological presentation forms and can therefore mimic other lesions, making their diagnosis challenging. Nonetheless, certain imaging aspects allow NENs to be included among the main differential diagnoses of hepatic lesions and can guide the search for an extrahepatic primary site when the probable diagnosis is metastases.
As neoplasias neuroendócrinas (NNEs) são um grupo heterogêneo de tumores com manifestações morfológicas e biológicas distintas, sendo o fígado o principal órgão acometido por suas metástases. Por outro lado, o acometimento primário deste órgão é muito raro. Podem-se observar as mais diversas formas de apresentação radiológica das NNEs hepáticas primária e secundária e, em razão dessa variedade e por mimetizar outras lesões, o seu diagnóstico pode se revelar um desafio. No entanto, alguns desses aspectos permitem incluir as NNEs entre os principais diagnósticos diferenciais de lesões hepáticas e, nos casos de metástases, orientar na busca de um eventual sítio primário extra-hepático.
ABSTRACT
Background:The use of meshes in hernia surgical repair promoted revolution in the surgical area; however, some difficulties had come, such as a large area of fibrosis, greater postoperative pain and risk of infection. The search for new substances that minimize these effects should be encouraged. Medicinal plants stand out due possible active ingredients that can act on these problems.Aim:To check the copaiba oil influence in the repair of abdominal defects in rats corrected with Vicryl(c) mesh. Method:Twenty-four Wistar rats were submitted to an abdominal defect and corrected with Vicryl(c) mesh. They were distributed into two groups: control and copaíba via gavage, administered for seven days after surgery. The analysis of the animals took place on 8, 15 and 22 postoperative days. It analyzed the amount of adhesions and microscopic analysis of the mesh.Results:There was no statistical difference regarding the amount of adhesions. All animals had signs of acute inflammation. In the control group, there were fewer macrophages in animals of the 8th compared to other days and greater amount of necrosis on day 8 than on day 22. In the copaiba group, the number of gigantocytes increased compared to the days analyzed.Conclusion:Copaiba oil showed an improvement in the inflammatory response accelerating its beginning; however, did not affect the amount of abdominal adhesions or collagen fibers.
Racional:A utilização de telas nas herniorrafias foi grande revolução na área cirúrgica; contudo, elas trouxeram algumas dificuldades, como grande área de fibrose, maior dor pós-operatória e risco de infecção. A busca por novas substâncias que minimizem esses efeitos deve ser estimulada. As plantas medicinais se destacam por apresentaram conjunto de princípios ativos que podem atuar em todos esses problemas.Objetivo:Verificar se o óleo de copaíba influência no reparo de defeitos abdominais em ratos corrigidos com tela de Vicryl®.Método:Vinte e quatro ratas Wistar foram submetidas a um defeito abdominal e corrigidos com tela de Vicryl®. Elas foram distribuídas em dois grupos: controle e copaíba via gavagem, administrada durante sete dias após a operação. A análise dos animais ocorreu nos dias 8, 15 e 22 de pós-operatório. Foi analisada a quantidade de aderências e feita análise microscópica da tela.Resultados:Não houve diferença estatística em relação à quantidade de aderências. Todos os animais tiveram sinais de inflamação aguda. No grupo controle, houve menor quantidade de macrófagos nos animais do dia 8 em relação aos demais dias e maior quantidade de necrose no dia 8 do que no dia 22. No grupo copaíba, o número de gigantócitos aumentou em relação aos dias analisados.Conclusão:O óleo de copaíba mostrou melhora na resposta inflamatória acelerando o seu início; contudo, não interferiu na quantidade de aderências abdominais ou fibras colágenas.
Subject(s)
Animals , Rats , Balsams/therapeutic use , Hernia, Ventral/surgery , Herniorrhaphy/instrumentation , Surgical Mesh , Rats, WistarABSTRACT
PURPOSE: To evaluate the effect of fasting on gastric emptying in mice. METHODS: Twenty-eight mice were distributed into three study groups: a normal group (N=4): normal standard animals; a total fasting group (N=12): subjected to food and water deprivation and a partial fasting group (N=12): subjected to food deprivation only. The fasting groups were subdivided into three subgroups of four animals each, according to the date of euthanasia: 24, 48 and 72 hours. Was analyzed: the gastric volume, degree of the gastric wall distention and the presence of food debris in gastrointestinal tract. RESULTS: The mean gastric volume was 1601 mm3in the normal group, 847 mm3in total fasting group and 997 mm3in partial fasting group. There was difference between the fasting groups in any analyzed period (p<0.05). Regarding the presence of food debris in the gastrointestinal tract and the degree of distension of the stomach, there was no difference between the groups that underwent total or partial fasting (p>0.05). CONCLUSION: Total fasting or only-solids deprivation does not induce gastric emptying in mice. .
Subject(s)
Aged , Female , Humans , Male , Aging/pathology , Alzheimer Disease/pathology , Brain/pathology , Image Interpretation, Computer-Assisted/methods , Magnetic Resonance Imaging/methods , Cognitive Dysfunction/pathology , Algorithms , Alzheimer Disease/complications , Computer Simulation , Diagnosis, Differential , Models, Statistical , Multivariate Analysis , Cognitive Dysfunction/complications , Pattern Recognition, Automated/methods , Reference Values , Reproducibility of Results , Sensitivity and SpecificityABSTRACT
PURPOSE: To evaluate the effects of copaiba oil on the correction of abdominal defect treated with the use of polypropylene/polyglecaprone mesh in rats. METHODS: A defect in the abdominal wall was created and corrected with polypropylene/polyglecaprone mesh in 36 rats. They were randomly distributed into three groups: control, copaiba by oral administration (gavage) and copaiba oil dip in the mesh. Euthanasia was performed after seven, 14 and 21 post-operative days. The healing process was analyzed regarding the meshes and macroscopic and microscopic aspects. RESULTS: All animals had abdominal adhesions, which were smaller in the copaiba (gavage) group (p<0.05). In microscopy, all animals had an acute inflammation stage and the inflammatory response was best characterized by foreign body-type granulomas around the mesh fragments, which was not found in the mesh fragments within the copaiba dip group. There was a greater area of necrosis and fibrosis in the copaiba dip group compared to the control group (p<0.05). The copaiba (gavage) group had a greater quantity of collagen fibers compared to the control group. CONCLUSION: Copaiba oil administered by gavage decreased the amount of abdominal adhesions, besides accelerating the process of collagen fibers formation, without damages within the early stages of healing. However, when used by dip directly on the mesh, it had corrosive effects compromising the healing process of the abdominal wall.
Subject(s)
Animals , Rats , Abdominal Wall/abnormalities , Dioxanes , Phytotherapy , Polyesters , Polypropylenes , Plant Preparations/therapeutic use , Surgical Mesh , Abdominal Muscles/abnormalities , Anti-Inflammatory Agents/therapeutic use , Collagen/biosynthesis , Drug Evaluation, Preclinical , Fibrosis , Granuloma, Foreign-Body , Necrosis , Random Allocation , Wound Healing/drug effectsABSTRACT
JUSTIFICATIVA E OBJETIVOS: A sepse é a principal causa de morte em unidades de terapia intensiva. Por esse motivo, é fundamental a procura de novos tratamentos para melhorar o manuseio dessa síndrome. O objetivo deste estudo foi verificar se o óleo de andiroba poderia ter um efeito benéfico na sepse abdominal, devido ao seu conhecido poder anti-inflamatório e antimicrobiano. MÉTODO: Foram utilizados 40 camundongos divididos em três grupos. Realizou-se sepse abdominal por meio da técnica de ligadura e perfuração cecal. O óleo de andiroba foi ministrado na dose de 0,5 mL diretamente na cavidade peritoneal. RESULTADOS: Houve diferença estatística significativa entre os grupos, sendo que o grupo tratado com óleo de andiroba apresentou menor sobrevida que os demais grupos. CONCLUSÃO: O tratamento com óleo de andiroba por via intraperitoneal diminuiu a sobrevida de camundongos submetidos à sepse.
BACKGROUND AND OBJECTIVES: Sepsis is the leading cause of death in intensive care units. Because of that, the search for new treatments to improve the management of this syndrome is crucial. The objective of this study is to check if andiroba oil could have a beneficial effect on abdominal sepsis, due to its known anti-inflammatory and antimicrobial properties. METHOD: A total of 40 mice divided into three groups was used. Abdominal sepsis was induced using the technique of cecal ligation and puncture. Andiroba oil was administered at a dose of 0.5 mL in the peritoneal cavity. RESULTS: There was a statistical difference between groups, with the group treated with andiroba oil showing lower survival than other groups. CONCLUSION: The intraperitonial treatment with andiroba oil decreased the survival of mice subjected to sepsis.